Delineating senescence in the context of brain-adipose axis in aging
The age-related loss of cognitive ability is highly variable between individuals as they age, and mechanisms that underlie the heterogeneous aspect of cognitive function have not been investigated. In this project, Dr. Logan addresses whether the metabolic dysfunction in the brain-adipose axis mediates heterogeneity in cognitive function with age. These studies are essential to understanding the molecular mechanisms by which peripheral adiposity contributes to cognitive decline with age that can potentially be leveraged to develop targeted therapies. Dr. Logan’s overarching hypothesis is that senescence in the brain-adipose axis impairs lipid metabolism, consequently, reduces healthspan that delineates cognitive trajectories in aging, and dietary interventions that promote lipid metabolism improve markers of senescence and inflammation.
