Aging Together: The Role of The Gut Microbiota and Its Influence on Host Immunity
Changes in the gut microbiome are linked to both healthy aging and the development of diseases. The gut microbiome undergoes significant changes as individuals age, and some of these changes can affect the immune system and increase the susceptibility to diseases. Dr. Ganesh’ research also suggests that certain microbial metabolites (secretory products), such as tryptophan-derived indoles, play a key role in reducing inflammation, which is associated with healthier aging. The study proposed utilizes animal models to investigate the impact of the gut microbiota in aging. Preliminary data provides evidence that as animals age, their gut microbiota becomes imbalanced and produces fewer beneficial metabolites including indole-derivatives. This imbalance is linked to increased inflammation and may contribute to aging and age-associated diseases. This proposal focuses on exploring whether introducing a "youthful gut microbiota" to aged animals can enhance the production of indole-derivatives, enhance beneficial immune function to promote healthier aging. Rejuvenating gut microbiota to improve quality of life in aging research is novel and through this this support Dr. Ganesh will investigate the use of youthful gut microbiota as a therapeutic tool to promote healthy aging.
