Rejuvenation of nuclear speckles to delay aging
The decline of proteostasis, encompassing the vital processes of protein production, secretion, and degradation, is intricately linked with the onset of aging and associated diseases. This connection underscores the critical need for innovative strategies to restore and maintain proteostasis, thereby potentially delaying the aging process and enhancing both health and lifespan. Dr. Zhu’s recent research highlights the importance of a dynamic process called nuclear speckles liquid-liquid phase separation (LLPS) in overseeing the overall protein health network. Dr. Zhu’s project is focused on advancing this understanding by genetically and pharmacologically enhancing the dynamics of nuclear speckles, an approach he refers to as "nuclear speckle rejuvenation." By doing so, he aims to significantly improve protein health, which is fundamental in maintaining cellular function and overall organismal vitality, to combat aging.
