Identifying clonal hematopoiesis resiliency mechanisms
This study seeks to find what makes some people resistant to an aging condition called clonal hematopoiesis. With age blood cells acquire mutations and as a result more than >10% of adults over 65 have clonal hematopoiesis. These mutated blood cells can cause many diseases including blood cancer as well as heart, brain, liver, and kidney diseases. Many people live a very long time with this condition but never get these diseases, which suggests that their bodies have ways to resist it. We plan to use information from over 1.5 million people to find out if certain genes or circulating proteins in the blood can prevent this condition and the diseases it can cause. This research could lead to new ways to prevent these diseases in older adults with clonal hematopoiesis, improving their quality of life.
