Inhibition of MTCH2 as a novel modality for ageing therapy
Have you ever wondered what makes some people live longer and healthier lives? While common wisdom suggests that balanced diet, regular sleep, exercise, and social interactions contribute to healthy aging, the deeper molecular secrets behind longevity remain largely unknown. Dr. Sidoli’s lab is on a quest to uncover these secrets. They are focusing on a fascinating aspect of our cells – the DNA and the proteins that interact with it, known as histones. As we age, our DNA becomes less stable, and the way our genes work begins to falter. Dr. Sidoli has discovered that a specific modification of these histones, called succinylation, seems to be more common in people likely to live exceptionally long lives, like those with centenarian parents. The goal is to understand how succinylation helps protect our DNA and potentially slows down the aging process. By understanding how succinylation influences aging, this could pave the way for new treatments and perhaps even dietary recommendations to help us live longer, healthier lives.
