Advancing Research
by funding Grant Programs and Fellowships
Driving Innovation
by guiding studies such as the FAST Initiative, the SuperAgers Initiative, and the TAME Trial
Furthering the Field
by supporting the infrastructure of three NIA Initiatives and leading the Amplifying Geroscience Initiative.
Top Breakthroughs driven by AFAR Experts
Delaying Disease by Targeting Aging
Saving Costs by Extending Healthspan
What are the Hallmarks of Aging?
What is Geroscience?
What is the Longevity Dividend?
In the proposed research, Dr. Nilay Yapici will use the fly model (Drosophila melanogaster) to identify behavioral, molecular, and neurophysiological changes in the brain over the lifespan. The study will use cutting edge technologies in multiphoton imaging, quantitative behavioral analysis, and single cell transcriptomics to observe the mechanisms of the brain that regulate age-related decline. The ultimate goal of this study is to understand the basic biology of the aging nervous system by identifying conserved neural and molecular mechanisms that regulate age-related decline, and eventually translate those findings to other animal models and humans.
