Advancing Research
by funding Grant Programs and Fellowships
Driving Innovation
by guiding studies such as the FAST Initiative, the SuperAgers Initiative, and the TAME Trial
Furthering the Field
by supporting the infrastructure of three NIA Initiatives and leading the Amplifying Geroscience Initiative.
Top Breakthroughs driven by AFAR Experts
Delaying Disease by Targeting Aging
Saving Costs by Extending Healthspan
What are the Hallmarks of Aging?
What is Geroscience?
What is the Longevity Dividend?
Epidemiological studies show a relationship between low oxygen levels (hypoxia) and longevity, with 7 of the 10 longest-lived US counties located at high altitudes in Colorado. Hypoxia-tolerant species, such as the naked mole rat, tend to be the longest-lived. Studies in worms have shown the activation of hypoxia transcriptional program increases longevity and protects against proteotoxicity. These previous studies, among others, indicate that oxygen levels have an impact on aging and longevity. In the proposed research, Dr. Isha Jain will investigate the role of oxygen in disease and metabolism, and explore the possibility of varying oxygen levels as therapy for age-associated neurodegeneration.
