Advancing Research
by funding Grant Programs and Fellowships
Driving Innovation
by guiding studies such as the FAST Initiative, the SuperAgers Initiative, and the TAME Trial
Furthering the Field
by supporting the infrastructure of three NIA Initiatives and leading the Amplifying Geroscience Initiative.
Top Breakthroughs driven by AFAR Experts
Delaying Disease by Targeting Aging
Saving Costs by Extending Healthspan
What are the Hallmarks of Aging?
What is Geroscience?
What is the Longevity Dividend?
Healthy aging is accompanied by a decline in cognitive faculties as well as a decline of the proteasome system. The proteasome system is a key driver of degradation of unneeded or damaged proteins. In preliminary studies, the Pickering lab have found that improving the proteasome system with novel genetic tools can slow or prevent cognitive decline in a fly model. In the proposed study, Dr. Andrew Pickering will investigate whether this improvement from augmentation of the proteasome system can be replicated in mammals. They will also investigate whether novel compounds that active proteasome function could delay cognitive deficits, which could lead to future interventions.
