Advancing Research
by funding Grant Programs and Fellowships
Driving Innovation
by guiding studies such as the FAST Initiative, the SuperAgers Initiative, and the TAME Trial
Furthering the Field
by supporting the infrastructure of three NIA Initiatives and leading the Amplifying Geroscience Initiative.
Top Breakthroughs driven by AFAR Experts
Delaying Disease by Targeting Aging
Saving Costs by Extending Healthspan
What are the Hallmarks of Aging?
What is Geroscience?
What is the Longevity Dividend?
As we age, our metabolism slows down and our fat tissues become enlarged and do not function normally. It is believed that stem cells in these fat tissues become unhealthy. In the proposed research, Dr. Daniel Berry will investigate methods of renewing stem cell function to improve fat tissue performance and fitness. For example, one method of improving fat tissue performance is encouraging the development of beige fat tissues, as beige fat cells are able to burn excess blood sugars and fats to generate heat creating an energy burning cycle. However, beige fat declines with age. Dr. Berry’s research will explore if the decline of beige fat is a result of stem cell aging/senescence and identify methods to influence the development of beige fat tissues that could ultimately lead to improved metabolic fitness and longevity
