2018

Glenn Foundation for Medical Research and AFAR Grants for Junior Faculty


Kevin Wang, MD, PhD

Assistant Professor, Stanford University School of Medicine

Rebooting the nuclear architecture as an innovative cellular reprogramming strategy to reverse aging

Dr. Wang's research takes advantage of an innovative genome engineering technology created in his laboratory (called CLOuD9) that enables reprogramming and re-organization of the three-dimensional architecture of our chromosomes as a new cellular rejuvenation strategy. His lab will characterize how chromatin, the complex of macromolecules found in cells, interacts with each other—much like origami—during normal development, aging, and premature aging disorders, and test whether cellular rejuvenation can be achieved through manipulation of chromatin architecture. His research will enable him to extend his lab's expertise and advance an important and complementary mechanism of cellular homeostasis.

More 2018 Recipients of this Grant

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Age-dependent decline of beige adipocyte induction and its metabolic consequences

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Kishore Kuchibhotla, PhD

Improving cognitive flexibility in aging by modulating context-dependent neural circuits

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Po-Ru Loh, PhD

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Andreas Pfenning, PhD

Cell type-specific epigenetic decay underlying brain aging

Andrew Pickering, PhD

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Vivek Venkatachalam, PhD

Whole brain dynamics in aging C. elegans

Deborah Winter, PhD

Uncovering the role of epigenomic reprogramming on monocyte development in aging

Nilay Yapici, PhD

Deciphering changes in the structure and function of neural circuits that regulate homeostatic drives during aging

Joshua Baker, MD, MSCE

Age and obesity-related alterations in skeletal muscle mitochondrial activity and lipid distribution, and associations with joint inflammation and cartilage degeneration in osteoarthritis