Rebooting the nuclear architecture as an innovative cellular reprogramming strategy to reverse aging
Dr. Wang's research takes advantage of an innovative genome engineering technology created in his laboratory (called CLOuD9) that enables reprogramming and re-organization of the three-dimensional architecture of our chromosomes as a new cellular rejuvenation strategy. His lab will characterize how chromatin, the complex of macromolecules found in cells, interacts with each other—much like origami—during normal development, aging, and premature aging disorders, and test whether cellular rejuvenation can be achieved through manipulation of chromatin architecture. His research will enable him to extend his lab's expertise and advance an important and complementary mechanism of cellular homeostasis.