Advancing Research
by funding Grant Programs and Fellowships
Driving Innovation
by guiding studies such as the FAST Initiative, the SuperAgers Initiative, and the TAME Trial
Furthering the Field
by supporting the infrastructure of three NIA Initiatives and leading the Amplifying Geroscience Initiative.
Top Breakthroughs driven by AFAR Experts
Delaying Disease by Targeting Aging
Saving Costs by Extending Healthspan
What are the Hallmarks of Aging?
What is Geroscience?
What is the Longevity Dividend?
The choroid plexus is a sheet of epithelial cells located in each of the brain's ventricles and is a major source of cerebrospinal fluid (CSF). Recent work shows that choroid plexus epithelial cells (CPECs) secrete age-dependent signals into the CSF that regulate neural stem cell proliferation, identity and overall brain health. However, much less is known about the CPECs capacity to take up and clear CSF-resident toxins such as β-amyloid (Aβ). The proposed study will investigate whether CPECs can be activated to promote clearance of the brain CSF, and if this activity-dependent clearance is impaired in the aging brain.
