Advancing Research
by funding Grant Programs and Fellowships
Driving Innovation
by guiding studies such as the FAST Initiative, the SuperAgers Initiative, and the TAME Trial
Furthering the Field
by supporting the infrastructure of three NIA Initiatives and leading the Amplifying Geroscience Initiative.
Top Breakthroughs driven by AFAR Experts
Delaying Disease by Targeting Aging
Saving Costs by Extending Healthspan
What are the Hallmarks of Aging?
What is Geroscience?
What is the Longevity Dividend?
As the body ages, it becomes more susceptible to injury and the skeletal muscle is harder to repair. In order to effectively repair skeletal muscle, the host needs well-coordinated and tightly controlled inflammatory response. Recent discoveries suggest that the successful resolution of inflammation needed to repair skeletal muscles is activity regulated by a new genus of specialized proresolving mediators (SPMs). SPMs are the enzyme metabolites of essential fatty acids. Aging is associated with more inflammation and slower resolution due to both more pro-inflammatory mediators and lower levels of SPMs. In the proposed study, Dr. James Markworth will investigate the role of SPMs in the resolution of inflammation and assess the therapeutic potential of immunoresolvent treatment in enhance muscle regeneration.
