Advancing Research
by funding Grant Programs and Fellowships
Driving Innovation
by guiding studies such as the FAST Initiative, the SuperAgers Initiative, and the TAME Trial
Furthering the Field
by supporting the infrastructure of three NIA Initiatives and leading the Amplifying Geroscience Initiative.
Top Breakthroughs driven by AFAR Experts
Delaying Disease by Targeting Aging
Saving Costs by Extending Healthspan
What are the Hallmarks of Aging?
How and Why Do We Age?
What is Geroscience?
What is the Longevity Dividend?
What's Next in aging research?
Stem cells are a unique group of cells that are essential to breathing, eating, moving, repairing wounds, and protecting the body from pathogens. With age, the behavior of stem cells changes. For example, they may experience an eroded lineage identity and grind to halt. This is particularly common in aging skin stem cells, which often display dual signs of being two different types of skin stem cells simultaneously. Dr. Yejing Ge will study the behavioral changes in stem cells with aging, particularly the erosion of lineage fidelity and how it leads to malfunction of the cells. The intention of the proposed study is to identify hallmarks of aged stem cells and devise novel strategies to harness their remarkable regenerative capacities to prolong human health span.
