Advancing Research
by funding Grant Programs and Fellowships
Driving Innovation
by guiding studies such as the FAST Initiative, the SuperAgers Initiative, and the TAME Trial
Furthering the Field
by supporting the infrastructure of three NIA Initiatives and leading the Amplifying Geroscience Initiative.
Top Breakthroughs driven by AFAR Experts
Delaying Disease by Targeting Aging
Saving Costs by Extending Healthspan
What are the Hallmarks of Aging?
How and Why Do We Age?
What is Geroscience?
What is the Longevity Dividend?
What's Next in aging research?
Aging has a profound effect on the brain, leading to age-related neurodegenerative diseases, such as Alzheimer’s disease, and other age-related cognitive impairments. In the proposed study, Dr. Geraldine Gontier will investigate how molecular mechanisms of an aging brain can be targeted to reverse the effects of aging. The approach involves manipulating master regulators of gene expression in an aging brain in order to express a more youthful state. The goal of the study is to better understand the molecular mechanisms involved in brain rejuvenation and provide a basis for further investigations on reversing aging in the brain.
