Ming Xu, PhD

Using senolytic drugs to alleviate age-related frailty and inflammation

Senescent cells induce inflammation in healthy organ tissue that could link them to age-related inflammation as well as frailty. The goal of this study is to better understand the role of cellular senescence in physical dysfunction, and to develop strategies to reduce frailty and improve physical function and resilience in an aging population. In the proposed study, Dr. Ming Xu will specifically examine if senescent, or “old”, cells cause frailty in aging adults, and whether senolytic drugs, which kill senescent cells, can reduce frailty while clearing out these “old” cells.