Wnt4 as a novel therapeutic for rejuvenating muscle stem cell function during aging
As we age, there is a gradual decline in the ability of muscles to repair and regenerate after trauma or injury. This age-related decrease in regenerative property is due to a decrease in the number and functionality of muscle tissue resident stem cells, also called Satellite Cells (SC), as well as changes in environmental cues. Dr. Eliazer’s research project will study the role of Wnt4 from the muscle fiber niche in regulating the maintenance of muscle stem cells. Wnt4 signaling may be a critical regulator of muscle stem cell function during aging and the manipulation of Wnt4 signaling has a high potential to rejuvenate aged muscle stem cell function. This research could lead to the development of therapies to maintain regenerative competence in muscle tissue after injury and trauma in the aged human population.
