Targeting vascular pathology to treat age-related cognitive decline
With aging, it becomes harder for cells to maintain cellular homeostasis. Our cells keep two genomes in separate areas, the nucleus and mitochondria, which each have genes that actively communicate with each other to keep our cells healthy. Dr. Jyung Mean Son will study how the mitochondria send messages to communicate with the nucleus to promote homeostasis and how this process changes during aging. The findings from this research could reveal how the mitochondrial and nuclear genomes co-evolved to independently encode for factors to cross-regulate each other. A greater understanding of how they communicate could be used for therapies to target aging and age-related disease.
