NSPR1 as an intersectional regulator of myelin and cognition in aging
Dr. Gibson’s research focuses on myelin-forming oligodendroglia, the cells that wrap around and insulate the axons connecting neurons, allowing for efficient neural communication within the brain. Specifically, her lab aims to understand how these cells contribute to the regulation of sleep and cognition in aging. Her lab identified alterations in neuropeptide S signaling, a known regulator of sleep and cognition, in oligodendrocytes with aging. Her AFAR-supported research focuses on deciphering the role of neuropeptide S signaling between neurons and oligodendroglia in the regulation of sleep, and how this may change with aging and contribute to aging-associated cognitive decline.