2025

McKnight Brain Research Foundation Innovator Awards in Cognitive Aging and Memory Loss


Acker Headshot

Leah Acker, MD, PHD

Assistant Professor, Duke University

Inflammatory Hangover and Cognitive Aging

Dr. Leah Acker is a practicing neurosurgical anesthesiologist and scientist at Duke University who leads the Anesthesiology, Cognitive Neuroscience, and Engineering Research (ACkER) Lab. The ACkER Lab is rethinking how to protect the aging brain before, during, and after surgery. Her multi-disciplinary team studies how the brain, heart, and immune system communicate to support recovery and long-term brain health. Using wearable sensors, brainwave recordings, and gentle, noninvasive nerve stimulation, they explore how small, repeated bouts of inflammation may quietly accelerate cognitive aging—a phenomenon called “the inflammatory hangover”—and how to prevent it. By translating discoveries in brain–body communication into practical tools, the ACkER Lab aims to help older adults recover from physiological stress more quickly, think more clearly, and maintain independence longer.

More 2025 Recipients of this Grant

Erin Gibson, PhD

NSPR1 as an intersectional regulator of myelin and cognition in aging

Erin Gibson