2009

AFAR Research Grant Program


Krums

Susan A. Krum, PhD

Assistant Professor, University of California, Los Angeles

Gene Regulation by Estrogen in Adipose of Aging Bone

Dr. Krum is studying the role estrogen plays in regulating bone and fat cells. More than 10 million Americans - most commonly post-menopausal women -- have osteoporosis. While estrogen provides protection against bone fractures by increasing bone mass and lowering fat accumulation, the mechanism by which it does this is unknown. Learning more about estrogen function could aid in better bone health, reducing the debilitating effects of fractures in the elderly.

More 2009 Recipients of this Grant

Joseph A. Baur, PhD

Does Mitochondrial Biogenesis Regulate Longevity?

Stephanie J. Bryant, PhD

Elucidating the Role of Biomechanical Factors in Age-related Changes in Cartilage: A Possible Risk Factor for Developing Osteoarthritis

Stephanie J. Bryant, PhD
Xin Chen, PhD

Histone Turnover During Stem Cell Homeostasis and Aging

Xin Chen, PhD
Heng-Jie Cheng, MD, PhD

Upregulation of Beta3-Adrenoceptors: A New Mechanism For Age-Dependent Decline in Cardiac Function and Beta-Adrenergic Reserve

Heng-Jie Cheng, MD, PhD
Audrey L. Duarte, PhD

The Effects of Aging on Associative Memory

Audrey L. Duarte, PhD
Jeffrey L. Dudycha, PhD

The Genetic Basis for the Evolutionary Divergence of Aging

Jeffrey L. Dudycha, PhD
Martin L. Duennwald, PhD

The Systems Biology of Age-Dependent Protein Misfolding

Martin L. Duennwald, PhD
Jonathan H. Lin, MD

Cellular Responses to Chronic Protein Misfolding

Jonathan H. Lin, MD
Goldis Malek, PhD

Osteopontin Regulation of Choroidal Neovascular Fibrosis through Macrophages

Goldis Malek, PhD
James R. Mitchell, PhD

Testing Small Molecule Inhibitors of GH/IGF-1 Receptor Signaling as Dietary Restriction Mimetics Against Acute Stress in vivo

James R. Mitchell, PhD
Raul Mostoslavsky, MD, PhD

SIRT6, a Chromatin Regulator of Glucose Homeostasis and Genomic Stability

Raul Mostoslavsky, MD, PhD
Nicolas Rohleder, PhD

Determinants and Consequences of the Acute Stress-induced Inflammatory Response in Human Aging

David W. Walker, PhD

Investigating the Life-extending Mechanisms of Apolipoprotein D: An Evolutionary Conserved Modulator of Oxidative Stress and Aging

Shuanhu (Joe) Zhou, PhD

The Effects of Niche on Mesenchymal Stem Cells During Human Skeletal Aging