2009

AFAR Research Grant Program


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Jonathan H. Lin, MD

Assistant Professor, University of California San Diego

Cellular Responses to Chronic Protein Misfolding

Protein misfolding underlies many age-related diseases including Alzheimer's disease, Parkinson's disease and macular degeneration. Dr. Lin will research the mechanisms by which human cells cope and adapt to protein misfolding or die. This may shed light into the pathogenesis of age-related diseases which could lead to new therapies to target these mechanisms.

More 2009 Recipients of this Grant

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Does Mitochondrial Biogenesis Regulate Longevity?

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Stephanie J. Bryant, PhD
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Histone Turnover During Stem Cell Homeostasis and Aging

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Upregulation of Beta3-Adrenoceptors: A New Mechanism For Age-Dependent Decline in Cardiac Function and Beta-Adrenergic Reserve

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Audrey L. Duarte, PhD

The Effects of Aging on Associative Memory

Audrey L. Duarte, PhD
Jeffrey L. Dudycha, PhD

The Genetic Basis for the Evolutionary Divergence of Aging

Jeffrey L. Dudycha, PhD
Martin L. Duennwald, PhD

The Systems Biology of Age-Dependent Protein Misfolding

Martin L. Duennwald, PhD
Susan A. Krum, PhD

Gene Regulation by Estrogen in Adipose of Aging Bone

Susan A. Krum, PhD
Goldis Malek, PhD

Osteopontin Regulation of Choroidal Neovascular Fibrosis through Macrophages

Goldis Malek, PhD
James R. Mitchell, PhD

Testing Small Molecule Inhibitors of GH/IGF-1 Receptor Signaling as Dietary Restriction Mimetics Against Acute Stress in vivo

James R. Mitchell, PhD
Raul Mostoslavsky, MD, PhD

SIRT6, a Chromatin Regulator of Glucose Homeostasis and Genomic Stability

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Nicolas Rohleder, PhD

Determinants and Consequences of the Acute Stress-induced Inflammatory Response in Human Aging

David W. Walker, PhD

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Shuanhu (Joe) Zhou, PhD

The Effects of Niche on Mesenchymal Stem Cells During Human Skeletal Aging