2009

AFAR Research Grant Program


Nicolas Rohleder, PhD

Assistant Professor, Brandeis University

Determinants and Consequences of the Acute Stress-induced Inflammatory Response in Human Aging

Rates of aging may be affected by how people handle stress. Dr. Rohleder's research will test the healthy and unhealthy response patterns of older adults to stress to determine if specific patterns affect biological, emotional and cognitive aging. One focus of the project will be the acute stress response of the inflammatory system, which has been associated with age-related diseases such as cardiovascular disease, type 2 diabetes, osteoporosis and some forms of cancer. The project will serve as the basis for a longitudinal study in which participants are tracked for up to five years to test long-term health consequences of specific response patterns. Understanding the effects of stress may allow for better preventative interventions that could result in healthier aging.

More 2009 Recipients of this Grant

Joseph A. Baur, PhD

Does Mitochondrial Biogenesis Regulate Longevity?

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Upregulation of Beta3-Adrenoceptors: A New Mechanism For Age-Dependent Decline in Cardiac Function and Beta-Adrenergic Reserve

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The Effects of Aging on Associative Memory

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Jeffrey L. Dudycha, PhD

The Genetic Basis for the Evolutionary Divergence of Aging

Jeffrey L. Dudycha, PhD
Martin L. Duennwald, PhD

The Systems Biology of Age-Dependent Protein Misfolding

Martin L. Duennwald, PhD
Susan A. Krum, PhD

Gene Regulation by Estrogen in Adipose of Aging Bone

Susan A. Krum, PhD
Jonathan H. Lin, MD

Cellular Responses to Chronic Protein Misfolding

Jonathan H. Lin, MD
Goldis Malek, PhD

Osteopontin Regulation of Choroidal Neovascular Fibrosis through Macrophages

Goldis Malek, PhD
James R. Mitchell, PhD

Testing Small Molecule Inhibitors of GH/IGF-1 Receptor Signaling as Dietary Restriction Mimetics Against Acute Stress in vivo

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SIRT6, a Chromatin Regulator of Glucose Homeostasis and Genomic Stability

Raul Mostoslavsky, MD, PhD
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The Effects of Niche on Mesenchymal Stem Cells During Human Skeletal Aging