Michael Lodato, PhD

Single-cell analysis of transcriptional instability and somatic mutation in human neurons

Human brain cells experience wear and tear during life. These random injuries likely drive cognitive decline and increased incidence of disease observed in the aging brain. Since the exact damage to each neuron might be unique to that cell, single-cell analysis is required to comprehensively study some age-associated changes. This proposal aims to apply new, single-cell methods to study the differences between cells of young and older human brain to find the exact changes that accompany aging.