Myc as the Driver of Cellular Epigenetic Rejuvenation in Skeletal Muscle
Skeletal muscle becomes smaller and weaker as aging progresses. The loss of muscle size and strength with age is problematic as it contributes to a loss of independence, reduced quality of life, and mortality. Exercise is a powerful countermeasure against the negative effects of aging and has beneficial effects in every system of the body. One such benefit is improved muscle mass and strength. Underlying improved muscle mass and strength gains with exercise are molecular processes such as changes in epigenetics and gene expression. Molecular changes in muscle cells can be mediated by transcription factors, some of which are responsive to exercise. The goal of this AFAR-supported project is to determine whether the exercise-responsive transcription factor Myc contributes to making skeletal muscle more youthful at the functional, cellular, epigenetic, and gene expression level. The knowledge gained from this work will shed light on exercise-associated factors that may support muscle “rejuvenation”.