Determinants regulating memory cell longevity and function in older adults
Age-associated changes to the human immune system render older individuals more vulnerable to new infections and to reactivation of latent viruses including Varicella-Zoster Virus (VZV). Although many vaccination strategies induce incomplete protection in older adults, the VZV vaccine Shingrix demonstrates the proof-of-principle that vaccines can be tailored specifically for the elderly. Understanding how long-term rather than short-lived immune memory can be accomplished in aged individuals is paramount for healthy aging. Dr. Sturmlechner’s research leverages VZV immunity as model system to uncover determinants of memory T cell longevity and function in older individuals. Her proposed studies are anticipated to elucidate the molecular mechanisms underlying waning of T cell immunity versus inducing efficient, long-lasting T cell memory in older adults. Findings could help promote healthy aging and advance vaccination strategies designed for the elderly population.
