2022

Glenn Foundation for Medical Research Postdoctoral Fellowships in Aging Research


Levine headshot

Daniel Levine, PhD

Postdoctoral Scholar, University of California San Francisco

Interrogating the Role of Epigenetic Signaling to PER2 in Healthful Adaptation to Calorie Restriction

Humans display a 24-hour periodicity in behavioral and molecular processes that deteriorates as they get older. Elderly individuals awaken earlier in the morning, sleep earlier at night, and have reduced molecular rhythms. While circadian abnormalities arise spontaneously during aging, similar syndromes are also observed throughout life in humans that harbor mutations in the circadian clock gene, PER2, and during feeding of the pro-longevity dietary intervention, calorie restriction. Understanding the mechanisms that link aging, calorie restriction, and the clock are essential for improving healthspan as genetic abrogation of the circadian clock in mice shortens lifespan and causes the development of age-associated morbidities. Dr. Levine’s research uses genetically modified mice that recapitulate behavioral and molecular abnormalities in circadian rhythms associated with aging and calorie restriction. His goal is to interrogate the mechanisms whereby the circadian clock senses calorie restriction to provide new therapeutic opportunities that improve healthspan.

More 2022 Recipients of this Grant

Matthew Bubak, PhD

Restoring the ability of aged muscle to adapt to aerobic exercise with heterochronic plasma transfer

Matthew Bubak
Chatrawee Duangjan, PhD

DCAF11/WDR23-dependent proteostasis mediates glucose and lipid handling

Chatrawee Duangjan
Silvana Duran-Ortiz, PhD

Determining the healthspan and senescent cell and DNA damage response status in long-lived mice with germline and adult-onset growth hormone receptor disruption

Silvana Duran-Ortiz
Yasar Arfat Kasu, PhD

Changes in ribosomal activity and proteostasis in hematopoietic stem cell aging

Yasar Arfat Kasu
Ekaterina Korotkevich, PhD

Identification of pathways connecting age-associated accumulation of mtDNA mutations with aging phenotypes

Ekaterina Korotkevich
Heidi Pak, PhD

Identification of Feeding Entrainment Mechanisms in a Calorie Restricted Diet

Heidi Pak
Ines Sturmlechner, PhD

Determinants regulating memory cell longevity and function in older adults

Ines Sturmlechner
Binsheng Wang, MD

Targeting p21Cip1-highly-expressing Cells to Improve Lifespan and Healthspan in Naturally Aged Mice

Binsheng Wang