Antigen identification of clonally expanded T cells in aging cerebrospinal fluid
Our understanding of the immune response to brain diseases such as age-related neurodegeneration is limited. Dr. Gate studies the interaction between the immune system and the brain. He believes that immune cells known as T cells can serve as 'sensors' of neurodegenerative diseases such as Alzheimer's and Parkinson's disease. His research aims to create systems-level analyses of adaptive immune processes to comprehensively and quantitatively evaluate the interactions between T cell molecular components and neurodegeneration. This unique strategy could enable the discovery of neurodegenerative disease antigens, which could serve as biomarkers or therapeutic targets.
