On August 26, 2020 Science Translational Medicine published research co-authored by AFAR experts Emily J. Davis, BA, and Dena Dubal, MD, PhD, on how the second X chromosome in women allows more variants of the gene KDM6A to provide an extra protective protein against Alzheimer’s disease. This may explain why women have a higher resilience to Alzheimer’s than men.
Ms. Davis is a 2017 Diana Jacobs Kalman/AFAR Scholarships for Research in the Biology of Aging recipient, and Graduate Student in Dr. Dubal’s Lab for Aging and the Brain at the University of California San Francisco.
Dr. Dubal is a 1998 Diana Jacobs Kalman/AFAR Scholarships for Research in the Biology of Aging recipient, a 2009 Paul B. Beeson Emerging Leaders Career Development Award in Aging recipient, and a 2015 Glenn Foundation for Medical Research and AFAR Grants for Junior Faculty recipient. She is also an Assistant Professor at the Weill Institute for Neurosciences at the University of California San Francisco.
Read the research, “A second X chromosome contributes to resilience in a mouse model of Alzheimer’s disease,” here.
Read a related press release here.
