On April 25th, 2025, Science Advances published research co-authored by AFAR grantees Jude Phillip, PhD, and Jeremy D. Walston, MD, on a new profiling platform designed to identify and classify functional subtypes of senescence in aging cells.
In a related NIH Research Matters article, Dr. Phillip explains: “We hope, with some more development, our technology will be used to help predict which drugs might work well for targeting senescent cells that contribute to specific diseases.”
This research was advanced in part thanks to the Glenn Foundation for Medical Research and AFAR Grants for Junior Faculty Dr. Phillip received in 2023. Dr. Phillip is also an Assistant Professor at Johns Hopkins University.
Dr. Walston a 1998 Paul B. Beeson Emerging Leaders Career Development Award in Aging recipient, the Raymond and Anna Lublin Professor of Geriatric Medicine at John Hopkins Medicine, and Chair of the Research and Dissemination Core of the Clin-STAR (Clinician-Scientists Transdisciplinary Aging Research) Coordinating Center, a National Institute on Aging (NIA) funded initiative managed by AFAR.
Read “Single-cell morphology encodes functional subtypes of senescence in aging human dermal fibroblasts” here.
The research was also highlighted in a related NIH Research Matters Article here.
Learn more about cellular senescence and senolytics here.
Science Advances is a journal of the American Association for the Advancement of Science.
