On May 17th, 2024, Science Advances Journal published research co-authored by AFAR Grantee Juan Pablo Palavicini, PhD, on the possible link between changes in the protein ACSS1-K635 and increased cell senescence and the development of a liver condition called nonalcoholic fatty liver disease.
The abstract states:
“Acetyl-CoA synthetase short-chain family member 1 (ACSS1) uses acetate to generate mitochondrial acetyl-CoA and is regulated by deacetylation by sirtuin 3. We generated an ACSS1-acetylation (Ac) mimic mouse, where lysine-635 was mutated to glutamine (K635Q) ...Thus, we propose that ACSS1-K635-Ac dysregulation leads to aberrant lipid metabolism, cellular senescence, and NAFLD.”
This research was advanced in part thanks to the Glenn Foundation for Medical Research and AFAR Grants for Junior Faculty Dr. Palavicini received in 2022.
Read the article, “Mitochondrial ACSS1-K635 acetylation knock-in mice exhibit altered metabolism, cell senescence, and nonalcoholic fatty liver disease” here.
Science Advances is a journal of the American Association for the Advancement of Sciences.
