On January 22nd, 2025, Nature published research co-authored by three-time AFAR Grantee Dena Dubal, MD, PhD, on the maternal X chromosome and cognition and brain aging in female mice.
In a related University of California, San Francisco (UCSF) press release Dr. Dubal shares, “These findings raise the possibility that some women who express more of their mom’s X chromosome just by pure chance may have more cognitive impairment with aging or an increased risk for diseases like Alzheimer’s.”
Dr. Dubal is a 1998 Diana Jacobs Kalman/AFAR Scholarships for Research in the Biology of Aging recipient, a 2009 Paul B. Beeson Emerging Leaders Career Development Award in Aging recipient, and a 2015 Glenn Foundation for Medical Research and AFAR Grants for Junior Faculty recipient.
Read the article “The maternal X chromosome affects cognition and brain ageing in female mice” here.
Read the related press release here.
For more insights on chromosomal sex differences in aging, watch AFAR’s Live Better Longer webinar with Prevention featuring Scientific Director Steven N. Austad, PhD, and Dr. Dubal here.
