2019

Glenn Foundation for Medical Research and AFAR Grants for Junior Faculty

Yarui Diao, PhD

Assistant Professor, Duke University School of Medicine

Identification and application of cis-regulatory enhancer elements for muscle stem cell function and muscle regeneration in aging

Dr. Diao plans to apply innovative genomics and genetics tools, to identify enhancer elements that play an essential role in the process of muscle stem cell aging, and to understand the gene regulatory mechanism that could be exploited to rejuvenate the aging phenotype in animals. He ultimately hopes to identify the “molecular handle” that can be utilized to fine tune the gene expression program and rejuvenate muscle stem cells in older adults.

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Carlos Aguilar, PhD

Deconstructing stem cell aging through interact-omics

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Nausica Arnoult, PhD

DNA Double Strand Break repair pathway choice and repair fidelity during cellular and organismal aging

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Abigail Buchwalter, PhD

Defining drivers and consequences of ribosome biogenesis deregulation during mammalian aging

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Lindsay De Biase, PhD

Regional differences in microglial lysosome function: implications for microglial aging and cognitive decline

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Brian DeBosch, MD, PhD

Activating the hepatic glucose fasting response to attenuate aging-related metabolic and autophagic defects

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Sung Min Han, PhD

Identifying genes that regulate mitochondrial positioning at the synapse during aging

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Mark McCormick, PhD

Measurement of the conservation in mammalian cells of the effects of lifespan-extending tRNA synthetase inhibitors

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Maria Mihaylova, PhD

Understanding the Effects of Dietary and Microbially Derived Metabolites on Gut Epithelial and Immune Cell Homeostasis During Aging

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Maria Mihaylova

A. Hunter Shain, PhD

Somatic mutation burden and aging in human skin

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A. Hunter Shain

Aakanksha Singhvi, PhD

Molecular investigation of glial roles in neural aging

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Aakanksha Singhvi

Peter Sudmant, PhD

Ultra-sensitive profiling of cell-type specific age-associated somatic mitochondrial mutational diversity

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Ming Xu, PhD

Targeting p21high senescent cells to improve healthspan and lifespan

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George Sutphin, PhD

Understanding the interplay between tryptophan and NAD metabolism during aging

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Kapil Ramachandran, PhD

Contributions and mechanisms of neuroproteasomes to brain aging

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Kapil Ramachandran

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