Vyacheslav Labunskyy
Vyacheslav Labunskyy - PhD
AFAR Research Grants for Junior Faculty - 2017
Vyacheslav Labunskyy

Vyacheslav Labunskyy - PhD

Assistant Professor - Boston University School of Medicine
Massachusetts, USA


AFAR Research Grants for Junior Faculty - 2017

Endoplasmic Reticulum (ER) stress resistance and longevity

The endoplasmic reticulum (ER) is a network of membranes found throughout a cell and connected to the nucleus. Stress on the ER has been shown to play an important role in aging and the development of many age-related human diseases, such as diabetes and cancer.

Cells adapt to ER stress by activating a protective mechanism known as the unfolded protein response (UPR). The UPR restores ER homeostasis by degrading misfolded proteins, inhibiting translation, and facilitating protein folding and secretion.

Although ER stress and protein misfolding are increasingly recognized as contributing factors to aging and aging-related diseases, the role of the UPR in regulating lifespan is not completely understood. Dr. Labunksyy and his team will explore the role of the UPR in aging using yeast as a model system. The team recently performed a forward genetic screen to identify yeast mutants that are resistant to ER stress induced by tunicamycin, a protein-inhibiting antibiotic. Dr. Labunskyy hopes to characterize the mechanisms of ER stress resistance in these mutants and test whether improved ER protein homeostasis promotes longevity. The team will also test whether activating the UPR will improve lifespan in yeast.

Dr. Labunskyy’s work will provide a better understanding of the mechanisms that underlie the link between ER stress resistance and longevity. This could facilitate the development of new therapeutic strategies to delay the aging process in humans.

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