Louis Lapierre
Louis Lapierre - PhD
AFAR Research Grants for Junior Faculty - 2015
Louis Lapierre

Louis Lapierre - PhD

Assistant Professor - Brown University
Rhode Island, United States


AFAR Research Grants for Junior Faculty - 2015

Study of the role of lipoprotein biogenesis in autophagy regulation and lifespan determination

Lipid secretion from key metabolic tissues, such as the liver and the intestine, is an important process that facilitates lipid transport to peripheral tissues. However, the role of lipid secretion in the maintenance and homeostasis of metabolic tissues remains unknown. Using the worm C. elegans as a model system, Dr. Lapierre’s lab is investigating how lipid-transporting lipoproteins affect lifespan.

Dr. Lapierre and his group recently found that elevated lipoprotein production (i.e. biogenesis) negatively affects the ability of an animal to live long. It does so in part by blocking the induction of autophagy, the digestion of cellular constituents.

Dr. Lapierre’s group seeks to elucidate how changes in the lipid profile of an animal affect autophagy and ultimately longevity. By determining the lipid makeup of animals with reduced lipoprotein biogenesis, the group aims to find novel lipid species that can increase longevity. They also hope their study will provide a rationale for developing therapeutics that can control lipoprotein biogenesis to prevent various diseases related to aging.

View all grantees for AFAR Research Grants for Junior Faculty in 2015

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