2016

Glenn Foundation for Medical Research and AFAR Grants for Junior Faculty


Gabrielle Fredman, PhD

Assistant Professor, Albany Medical College

Specialized Pro-Resolving Mediators in Aging

As we age, our ability to recover from injury or illness diminishes, and makes us more susceptible to diseases like arthritis, macular degeneration and atherosclerosis, to name a few. A persistent low-grade inflammation associated with aging (inflammaging) may be the underlying cause. Previously it was thought that inflammation ceased due to passive means. It is now widely appreciated that the resolution of inflammation is a highly active process that is largely controlled by specialized pro-resolving mediators. Dr. Fredman and her group seek to understand the mechanisms of impaired resolution (i.e. the inability to end) of inflammation in aging and to use signaling pathways to create new therapies to suppress inflammation.

More 2016 Recipients of this Grant

Hua Bai, PhD

Ligand-specific regulation of TGF-beta mediated muscle aging and longevity

Jennifer Garrison, PhD

Investigating the role of oxytocin signaling in aging

Eric Greer, PhD

Transgenerational Epigenetic Inheritance of Longevity

Guo Huang, PhD

Cardiac Regenerative Potential in Mammalian Development and Aging

Changhan Lee, PhD

A Novel Mitochondrial-Encoded Regulator of Aging Metabolism

Scott Leiser, PhD

A conserved role of flavin-containing monooxygenases in promoting stress resistance, health and longevity

Joseph Rodgers, PhD

The effects of mitochondrial biogenesis on stem cell dysfunction and impaired healing in aging

Brain Zid, PhD

Many age-related diseases, including Alzheimer’s disease, Parkinson’s disease and Amyotrophic Lateral Sclerosis, are associated