Interrogating the functional role of aged stem cell niche interactions in the hair follicle
Stem cell exhaustion is a hallmark of aging that unfolds as a consequence of a complicated network of both intrinsic and extrinsic factors. Using the human hair follicle as a model system, Dr. Tierney’s research aims to distinguish between the defects present in aged stem cells from progressive deterioration in their local environment. By isolating and reconstructing essential elements of stem cell-niche crosstalk in defined conditions, these studies may improve our understanding of the true drivers of stem cell aging. Long-term, his work aspires find application in regenerative medicine approaches designed to ameliorate age-associated declines in stem cell function and tissue fitness.
