On February 26th, 2024, Aging Cell published research co-authored by 2013 AFAR Grantee Mark E. Kleinman, MD, on histone dynamics, cellular senescence, and aging.
The abstract states:
“Histones serve as a major carrier of epigenetic information in the form of post-translational modifications which are vital for controlling gene expression, maintaining cell identity, and ensuring proper cellular function…These findings strongly demonstrate histone loss as a unique feature of RPE aging and provide critical insights into the potential mechanisms linking histone dynamics, cellular senescence, and aging.”
This research advanced thanks in part to early support from The AFAR Research Grant Program.
Read the article, “Histone deficiency and hypoacetylation in the aging retinal pigment epithelium” here.
