2022

Hevolution/AFAR New Investigator Awards in Aging Biology and Geroscience Research


Beck Headshot

Samuel Beck, PhD

Associate Professor, Boston University School of Medicine

Big data-guided anti-aging drug discovery and its validation

Although aging is an inevitable process of human life, the rate of physiological deterioration is controllable. Physical exercise, heterochronic parabiosis, nutritional and pharmacological intervention have proven to be successful in slowing the rate of physiological deterioration. To lessen the massive socioeconomic burden of aging, it is imperative to develop safe and easily applicable anti-aging pharmaceutics. Notably, systematic profiling and analysis of previously generated NextGen sequencing data will enable the rapid discovery of new anti-aging pharmaceutics. Dr. Beck's research aims to identify and validate new and effective anti-aging pharmaceutics by taking advantage of big data analytics using a novel transcriptomic biomarker of aging.

More 2022 Recipients of this Grant

Charlotte Cecil, PhD

What makes clocks tick? Mapping determinants of epigenetic age acceleration in early life

Charlotte Cecil
Marco Demaria, PhD

Targeting altered Ca2+ signaling in cellular senescence to extend healthy longevity

Marco Demaria
Peter Douglas, PhD

Intracellular lipid surveillance and nuclear hormone receptor dynamics in age determination

Peter Douglas
Nir Eynon, PhD

Uncovering sex-specific epigenetic ageing molecules in response to exercise

Nir Eynon
Aditi Gurkar, PhD

A Nanoscale Detection Tool for Senescence

Aditi Gurkar
Diana Jurk, PhD

Investigating liver-to-brain transmission of cellular senescence during aging

Diana Jurk
Adam Konopka, PhD

Interaction of Rapamycin and Exercise on Healthspan

Adam Konopka
Sailendra Nichenametla, PhD

Investigating the role of serinogenesis in regulating lipid metabolism

Sailendra Nichenametla
Miranda Orr, PhD

Spatial proteogenomic profiling to determine the impact of senescent neurons on the aging brain

Miranda Orr
Daniel Roh, PhD

Targeting Wound Senescence to Improve Wound Healing in Aging

Daniel Roh
Markus Schosserer, PhD

Targeting the epitranscriptome to promote healthy lifespan

Markus Schosserer
Kosaku Shinoda, PhD

Proper Control of Inflammatory Cell Death during Aging of Brown Adipose Tissue (BAT)

Kosaku Shinoda
Marlene Starr, PhD

The Role of Adipose Tissue-Resident γδ T Cells in Age-Associated Inflammation and Metabolic Dysfunction

Marlene Starr
Stefano Tarantini, PhD

Intravital characterization of mitochondrial dysfunction in the aged brain endothelium

Stefano Tarantini
Lindsay Wu, PhD

Overcoming ovarian failure to extend women's health and lifespan

Lindsay Wu
Ming Xu, PhD

The synergistic benefits of metformin and senolytics on lifespan and healthspan

Ming Xu
Zhixun Dou, PhD

Loss of nuclear proteostasis in senescence and aging

Zhixun Dou