The effects of kynurenine pathway manipulation on metabolism and healthspan in mice
The Kynurenine pathway (KP) is a conserved molecular pathway that is activated with inflammation, aging, and frailty in mammals, including humans. Genetic and pharmacological manipulation of this pathway can both positively and negatively influence lifespan in lower organisms, depending on whether the pathway is activated or suppressed. However, it is not known if altering this pathway can affect healthspan and lifespan in mammals. In this study Dr. Westbrook will examine changes in the kynurenine pathway that occur with aging and inflammation and determine if manipulating this pathway affects aging and physical function in mice. This study aims to shed light on the etiological role of the KP in the development of inflammation-related functional decline and aging in mice.
