Molecular and Cellular Mechanisms of extreme longevity and global tissue rejuvenation
Dr. Longhua Guo’s research studies aging, regeneration and global tissue rejuvenation in long-lived animals such as planarians and leopard geckos. His AFAR supported research will use the long-lived sexual planarians to dissect the mechanisms underlying tissue-specific aging rates and species-specific aging rates, in addition to mechanisms leading to rejuvenation. This research establishes planarians as a laboratory model organism to understand the basic biology of aging in a long-lived organism, and novel strategies of tissue rejuvenation. Dr. Guo’s research may inspire new methods to reverse age-related diseases in elderly humans.
