Deciphering functional subtypes of senescence at single-cell resolution
Dr. Phillip’s research vision builds on a strong multi-disciplinary background, applying engineering at the intersections of biology and medicine. Working closely with clinicians, his lab leverages deep single cell profiling, technology development and data science to comprehensively study aging in health and disease. His previous work showed that aging information was encoded within biophysical characteristics of cells, for instance how they move, spread, and exert forces within local microenvironments. His AFAR-supported research will develop a new single-cell profiling platform to identify and classify functional subtypes of senescence in aging cells. Defining these functional subtypes of senescence is critical as it could lead to more accurate identification and classification of senescent cells and enhance our current understanding on the effects of age.
