Understanding Gzmk+ CD8+ T Cell Development and Activity in Aging
Significant changes occur in the immune system with age. T lymphocytes are crucial for fighting infections and cancer but change considerably with age. There is a subset known as Age-Associated T cells (TAA cells) which are cytotoxic CD8+ T cells that express Granzyme K (Gzmk). These accumulate in old age and likely contribute to immunosenescence and disease in older adults. We are focusing on understanding what drives the development and function of Gzmk+ CD8+ TAA cells during aging. Dr. Tyrrell will explore the role of antigen exposure and Granzyme K on development and cytotoxicity of TAA cells. His team will examine TAA cells longitudinally across the lifespan to better understand TAA cell regulation, cytotoxic mechanisms, and their impact on healthy aging. This research aims to uncover insights into immune aging and potentially identify novel immunomodulatory therapeutic targets for disease in older adults.
