Neuronal regulation of histone acetylation promotes longevity
Aging is a complex process influenced by internal and external factors, with the environment playing a critical role. In fact, external factors regulate around 70% of the human lifespan, which means that the interaction between our genes and the environment is fundamental to our health. The nervous system is vital in processing complex information from the environment, which ultimately affects how animals age. It is responsible for integrating external inputs and communicating them to peripheral tissues to maintain whole-body balance. However, our understanding of how these neuronal signals modulate aging remains inchoate. Dr. Silva Garcia proposes to study these signals by manipulating neuronal pathways to promote healthy aging and longevity and identifying the downstream mechanisms. Humans are brain-centered, controlling behavior, emotions, physiology, and responses. Therefore, targeting neuronal pathways is a promising strategy to promote healthy aging.
