Po-Ru Loh
Po-Ru Loh - PhD
AFAR Research Grants for Junior Faculty - 2018
Po-Ru Loh

Po-Ru Loh - PhD

Assistant Professor - Brigham and Women's Hospital/Harvard Medical School
Massachusetts, USA


AFAR Research Grants for Junior Faculty - 2018

Understanding the etiology and effects of age-related clonal hematopoiesis

At birth, our blood cells all contain the same genetic information from our parents. However, as we age, genetic mutations can occur and proliferate within our blood (clonal hematopoiesis). Dr. Po-Ru Loh’s research has the potential to help tease apart the differences between subtypes of age-related clonal hematopoiesis. Clonal expansions of blood cells carrying some types of mutations are harbingers of disease, while clonal expansions involving other types of mutations can be considered a normal part of healthy aging.

In the proposed research, Dr. Po-Ru Loh will use very large genetic studies to look for clues as to why these mutations arise and to investigate the effects of different mutations on health. Dr. Loh will seek to identify types of acquired mutations with strong links to aging and age-related diseases while also looking for a link between telomere length, a biomarker of aging, and clonal hematopoiesis.

View all grantees for AFAR Research Grants for Junior Faculty in 2018

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