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Grantees in the News: Barzilai and Atzmon discover mutation that protects against type 2 diabetes

Mar 3
2014

Grantees in the News: Barzilai and Atzmon discover mutation that protects against type 2 diabetes View MoreBACK

2011 AFAR Grant recipient Gil Atzmon, Ph.D. and AFAR Deputy Scientific Director Nir Barzilai, M.D., were among the co-authors of a study published on March 2, 2014 in the journal Nature Genetics that identifies a genetic mutation that protects again type 2 diabetes, even for those considered to be at-risk.

The study was based on the genetic testing of 150,000 people and found that this particular mutation, which destroys a gene used by pancreas cells where insulin is made, reduces the risk of the development of the disease by two-thirds. Individuals with the gene mutation produce more insulin and have lower blood glucose levels than those without it. Going forward, drug companies will use these findings to develop medications that mimic the mutation.

The study was profiled in the New York Times on March 2, 2014

Dr. Atzmon is an Associate Professor in the Division of Endocrinology, Department of Medicine, at Albert Einstein College of Medicine. He was a 2011 recipient of an AFAR Award in the Biology of Aging.

Dr. Barzilai is the Director of the Institute for Aging Research at the Albert Einstein College of Medicine and the Director of the Paul F. Glenn Center for the Biology of Human Aging Research and of the National Institutes of Health’s (NIH) Nathan Shock Centers of Excellence in the Basic Biology of Aging. He received an AFAR Award in 1994 and a Paul F. Beeson Development Award in Aging Research in 1997. He is a member of the AFAR Board of Directors.





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