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Grantees in News: Hansen and Kumsta on heat stress and autophagy in Nature and Science

Feb 23
2017

Grantees in News: Hansen and Kumsta on heat stress and autophagy in Nature and Science View MoreBACK

On February 15, 2017, Nature Communications published research led by 2014 Julie Martin Mid-Career Award in Aging Research recipient Malene Hanson, PhD with 2013 Ellison Medical Foundation/AFAR Postdoctoral Fellows in Aging Research Program recipient Caroline Kumsta, PhD.

In “Hormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. elegans,” Hansen and Kumsta looked at the effect of heat on cellular stress of the C. elegans worm. Their findings demonstrate that the cellular process of autophagy contributes to stress resistance.

In a related article in Science Magazine, “What doesn’t kill you makes your stronger,” Hansen notes:

"Our finding that brief heat exposure helps alleviate protein aggregation is exciting because it could lead to new approaches to slow the advance of neurodegenerative diseases such as Huntington's," says Hansen. "The results may also be relevant to Alzheimer's and Parkinson's, which are similarly caused by clumping-prone proteins."

In a related video, Kumsta explains how this cellular recycling process may link to beneficial effects of enduring mild stress.

Malene Hansen, PhD, is an Associate Professor of Development, Aging and Regeneration Program at Sanford Burnham Prebys Medical Discovery Institute.

Caroline Kumsta, PhD, is a senior scientist in Hansen’s lab.


For more on Dr. Hansen’s research, check out this Grantee Spotlight interview.
 





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