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Grantee in the News: Rose-Anne Kenny and Matthew D. L. O’Connell on the Systolic Blood Pressure Intervention Trial in JAMA

Jul 20
2017

Grantee in the News: Rose-Anne Kenny and Matthew D. L. O’Connell on the Systolic Blood Pressure Intervention Trial in JAMA View MoreBACK

On July 17, 2017, The Journal of the American Medical Association (JAMA) published research from 1998 Paul B. Beeson Emerging Leaders Career Development Award in Aging scholar Rose-Anne Kenny, MD and 2015 Paul B. Beeson Emerging Leaders Career Development Award in Aging CARDI scholar Matthew D. L. O’Connell, PhD on their Systolic Blood Pressure Intervention Trial (SPRINT).

The study, Injurious Falls and Syncope in Older Community-Dwelling Adults Meeting Inclusion Criteria for SPRINT, compared adults with hypertension aged 75 years or older participating in The Irish Longitudinal Study on Aging (TILDA) with the control arm of SPRINT. SPRINT treated older adults with an aggressive systolic blood pressure (BP) target of 120 mm Hg instead of 140 mm Hg.

The researchers saw a significant reduction in cardiovascular events and deaths in older adults in SPRINT compared to TILDA.

The study found that injurious falls were reported in 27.3% of the TILDA group and only 5.5% of the SPRINT group. Syncope was reported in 13.3% of the TILDA group versus 2.4% of the SPRINT group.
In a related featured story, researchers told MedPage Today: "Given the high baseline rates of falls and syncope, any increase in these rates due to intensive treatment of hypertension could result in harm."

The full JAMA study is only accessible with a subscription, but an abstract is available here.

The research was recognized in a related feature story in MedPage Today that can be viewed here.

Rose-Anne Kenny, MD is a Professor of Medical Gerontology and Head of the academic Discipline of Medical Gerontology at Trinity College Dublin.

Matthew D. L. O’Connell, PhD is a Paul B. Beeson Emerging Leaders Career Development Award in Aging CARDI fellow at Trinity College Dublin.





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