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Grantee in the News: Reisa Sperling’s research published in JAMA Neurology on vascular risk and cognitive decline

May 30
2018

Grantee in the News: Reisa Sperling’s research published in JAMA Neurology on vascular risk and cognitive decline View MoreBACK

On May 21, 2018, JAMA Neurology published research co-authored by 2003 Paul B. Beeson Emerging Leader Career Development Award in Aging recipient Reisa Sperling M.D., M.M.Sc.

Interactive Associations of Vascular Risk and β-Amyloid Burden with Cognitive Decline in Clinically Normal Elderly Individuals” presents findings from a longitudinal observational study that examined clinically normal older adults in the Harvard Aging Brain Study. The researchers found that “vascular risk has a potent association with longitudinal cognitive decline, both alone and synergistically with Aβ burden in clinically normal older adults.”

The research was picked up by ScienceDaily, where Dr. Sperling states: “It's important to keep in mind that the Harvard Aging Brain Study enrolls pretty healthy older individuals who do not have very high levels of vascular disease. But even so, these results suggest that even relatively modest levels of vascular risk can interact with very early Alzheimer's disease pathology to hasten cognitive decline in normal older individuals."

Read the published research here. Related articles by ScienceDaily and ScienceNewsline are available here and here.


Reisa Sperling, M.D., M.M.Sc. is the Director of the Center for Alzheimer's Research and Treatment and Co-investigator at the Neuroimaging Core at the Massachusetts Alzheimer's Disease Research Center. She is also a Professor of Neurology at Harvard Medical School.





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