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Grantee in the News: Domenico Praticò, MD on earliest sign of Alzheimer’s and preventative protein

Mar 23
2017

Grantee in the News: Domenico Praticò, MD on earliest sign of Alzheimer’s and preventative protein View MoreBACK

On March 8, 2017, Rawstory.com reported on findings from 1999 AFAR/Pfizer Innovations in Aging Research Award recipient Domenico Praticò, M.D. on detecting and preventing Alzheimer’s disease, originally published in the online journal Translational Psychiatry.

Dr. Praticò and his research team proved declining glucose levels in the brain are a direct trigger for cognitive impairments related to Alzheimer’s. To discover this earlier sign of the disease is groundbreaking. Before this finding, memory loss and cognitive decline were the earliest signs of Alzheimer’s. Knowing declining brain glucose levels before other symptoms appear give researchers a greater opportunity to prevent the neurodegenerative disorder.

Their research has also found a potential candidate for a promising drug development, a protein known as p38, to prevent this decline in brain glucose levels. Dr. Praticò responded, "The findings are very exciting, there is now a lot of evidence to suggest that p38 is involved in the development of Alzheimer's disease."

Read the full article here.

Dr. Domenico Praticò is a Professor in the Center for Translational Medicine at the Lewis Katz School of Medicine at Temple University.


To learn more about Alzheimer’s, review the expert-edited InfoAging Guide to Alzheimer’s disease.





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