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Grantee in the News: Domenico Praticò in Molecular Neurobiology on reversing brain damage from dementia in mice

Jun 20
2018

Grantee in the News: Domenico Praticò in Molecular Neurobiology on reversing brain damage from dementia in mice View MoreBACK

On June 7, 2018, Molecular Neurobiology published research co-authored by 1997 AFAR Research Grant and 1999 AFAR/Pfizer Innovations in Aging Research Award recipient Domenico Praticò, M.D.

In “Learning Impairments, Memory Deficits, and Neuropathology in Aged Tau Transgenic Mice Are Dependent on Leukotrienes Biosynthesis: Role of the cdk5 Kinase Pathway,” Dr. Pratico and his team found that “the first demonstration that the leukotriene biosynthesis is functionally involved at the later stages of the tau pathological phenotype and represents an ideal target with viable therapeutic potential for treating human tauopathies.”

In a related article in ScienceAlert, Dr. Praticò comments on the importance of these finding: "It's really dramatic what we observed…For the first time, we are showing that we can do something after the disease is established."

The research is available by subscription-only here, but related articles in ScienceAlert and Science Daily can be read here and here.


Dr. Domenico Praticò is a Professor at Temple University School of Medicine.





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